Acnetrex Isotretinoin 10-20mg 30 capsules

Composition
active substance: isotretinoin;
1 capsule contains 20 mg of isotretinoin;
auxiliary substances: white wax, butylhydroxyanisole (E 320), disodium edetate, hydrogenated vegetable oil, soybean oil;
gelatin capsules: gelatin, glycerin, sorbitol 70% solution (E 420), carmoisine (E 122), diamond blue (E 133), ponzo 4R (E 124), iron oxide black (E 172), titanium dioxide (E 171) , the water is purified.

Indication
Severe forms of acne (in particular, nodular and conglobat acne, acne with a tendency to permanent scarring) that do not respond to standard treatment methods (systemic antibacterial therapy, local treatment).

Method of application
Standard dosing regimen

Treatment with isotretinoin should be prescribed and administered only by a physician experienced in the use of systemic retinoids for the treatment of severe acne and fully aware of the risks of retinoid therapy and the requirements for patient monitoring.

Capsules are taken with meals 1‒2 times a day.

Adults (including teenagers and the elderly). Treatment should be started with a dose of 0.5 mg/kg per day. The therapeutic response to isotretinoin and some adverse reactions are dose dependent and vary between patients. In this regard, individual correction of the dose during treatment is necessary. In most patients, the dose ranges from 0.5 to 1 mg/kg of body weight per day.

Long-term remission and relapse rates are more related to the total dose administered than to the duration of treatment or the daily dose. It has been proven that no additional benefit should be expected when using a course dose higher than 120‒150 mg/kg. The duration of therapy depends on the daily dose. A course of treatment of 16‒24 weeks is usually enough to achieve remission.

In most patients, acne disappears completely after a single course of treatment. In case of a pronounced relapse, a second course of treatment with Acnetrex should be carried out in the same daily and course dose as the first. Since the condition can improve within 8 weeks after the end of treatment, a repeat course should be prescribed no earlier than the end of this period.