Orcerin Diacerein 50mg 30 caps

Orcerin Composition
active ingredient: diacerein;

1 capsule contains diacerein 50 mg;

excipients: cyclodextrins, sodium lauryl sulfate, lactose monohydrate, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate;

capsule composition: diamond blue (E 133), ponceau 4R (E 124), quinoline yellow (E 104), titanium dioxide (E 171), sodium lauryl sulfate, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), gelatin.

Indications
Treatment of patients with symptoms of osteoarthritis of the hip or knee, with delayed effect.

Treatment with diacerein is not recommended for patients with rapidly progressive osteoarthritis of the hip, as they may have a poor response to diacerein.

Method of administration and dosage
Treatment should only be initiated by physicians experienced in the treatment of osteoarthritis.

During the first 2-4 weeks of treatment, adults take 1 capsule (50 mg) with the evening meal, washed down with water. From the 2-4th week of treatment, the dose of the drug is increased to 100 mg per day in 2 doses (1 capsule in the morning and evening during meals). Diacerein has a slow, delayed initial activity and a residual effect after discontinuation of treatment, as a result of which Orcerin should be used for at least 2-4 weeks before the first positive effect appears. The positive symptomatic effect persists for 3 months after the period of use. Given the nature of the disease, a long course of treatment is recommended – at least 3 months, which can be repeated if symptoms appear.

The duration of the course of treatment is determined individually by the doctor.

Elderly patients

Diacerein is not recommended for patients aged 65 years and older due to the fact that this category is more vulnerable to complications associated with diarrhea.

No significant changes in pharmacokinetic parameters have been observed when using diacerein in elderly patients, therefore, there is no need to use the recommended dose (see section “Pharmacodynamics”). However, caution is required when prescribing Orcerin to elderly patients. If diarrhea occurs, treatment with diacerein should be discontinued.

Patients with chronic renal failure.

Patients with mild and moderate renal failure do not need to change the usual recommended dose. However, for patients with severe renal failure (creatinine clearance < 30 mg/ml), the daily dose should be reduced by 50% of the recommended dose (corresponding to 50 mg per day).