Pharmacotherapeutic group: Cardiac drugs. ATX code С01Е Х.
Composition:
active ingredient Corvalment: menthol solution in menthol ester of isovaleric acid
1 capsule contains menthol solution in menthol ester of isovaleric acid 100 mg auxiliary substances Corvalment: gelatin, glycerin.
Dosage form: Soft capsules.
Basic physical and chemical properties: soft gelatin capsules of a spherical or spherical shape, with a seam, colorless or from slightly yellow to light brownish yellow, filled with a transparent colorless or with a yellowish tinge oily liquid with the smell of menthol.
Pharmacodynamics:
The drug exhibits a calming effect on the central nervous system, and also has a moderate reflex vasodilator (coronarolytic) effect by reflex irritation of sensitive nerve (“cold”) receptors of the oral mucosa. Stimulation of receptors is accompanied by the induction of the release of endorphins, enkephalins, dynorphins and other peptides, histamine, kinins, which play an important role in reducing pain sensitivity, normalizing vascular permeability and regulating other important mechanisms of the functioning of the cardiovascular and nervous systems.
Pharmacokinetics:
When administered sublingually, drug is absorbed from the oral mucosa. The therapeutic effect occurs in about 5 minutes. After absorption, it is biotransformed in the liver and excreted in the urine in the form of glucuronides.
Interaction with other medicinal products and other forms of interaction:
Corvalment enhances the sedative effect of psychotropic drugs, opioid analgesics, alcohol and anesthetics when used simultaneously. Potentiation of the action of antihypertensive drugs is possible when used simultaneously with the drug. Corvalment reduces the severity of headaches caused by the intake of nitrates.
Application features:
In cases where pain in the heart area does not go away after taking the drug, it is imperative to consult a doctor to exclude acute coronary syndrome. The medicinal product does not contain sugar and can be used by patients with diabetes mellitus.
Caution is needed in the first hours after taking the drug when driving or working that requires increased attention, due to possible side effects (dizziness and drowsiness).
Application during pregnancy or lactation The use of the drug during pregnancy or lactation is possible if, in the opinion of the doctor, the expected positive effect for the mother outweighs the potential risk for the fetus / child.
There is no experience of using the drug for the treatment of children.
Overdose:
Symptoms: headache, nausea, agitation, impaired heart function, decreased blood pressure, depression of the central nervous system, hypersensitivity reactions to the components of the drug (angioedema, urticaria, itching, rash). Treatment: drug withdrawal and symptomatic therapy.
Adverse Reactions:
With prolonged use, occasionally mild nausea, abdominal discomfort, lacrimation, dizziness, short-term arterial hypotension, drowsiness, which quickly pass on their own, may occur. Allergic reactions may develop, including Quincke’s edema, urticaria, rash, itching.
Indications:
Mild angina attacks;
sea and air sickness;
hysteria;
neurosis;
headache associated with taking nitrates.
Contraindications:
Hypersensitivity to drug components.
Severe arterial hypotension, acute myocardial infarction.
Method of administration and dosage:
Keep the capsule in the mouth (under the tongue) until it is completely dissolved. To accelerate the effect, you can crush the capsule with your teeth. Single dose – 1 capsule (100 mg). The maximum daily dose is 6 capsules (600 mg). The duration of treatment is up to 7 days.
Pharmacodynamics:
The drug exhibits a calming effect on the central nervous system, and also has a moderate reflex vasodilator (coronarolytic) effect by reflex irritation of sensitive nerve (“cold”) receptors of the oral mucosa. Stimulation of receptors is accompanied by the induction of the release of endorphins, enkephalins, dynorphins and other peptides, histamine, kinins, which play an important role in reducing pain sensitivity, normalizing vascular permeability and regulating other important mechanisms of the functioning of the cardiovascular and nervous systems.
Shelf life:
3 years.
Storage conditions:
Store Corvalment in its original packaging at a temperature not exceeding 25 ° C.
Packaging: 20 capsules in a blister; 4 blisters in a pack.
Non prescription drug
Produced in Ukraine
