PHENIHIDIN (Nifedipindum) Tablets 10 mg №50

Phenihidin (nifedipine)

Phenihidin contains the active ingredient nifedipine, dihydropyridine calcium channel blocker.

Phenihidin has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, Phenihidin prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Phenihidin is used to treat hypertension and chronic stable angina.
INDICATION:
For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud’s phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

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